Daily Bolus of LR: Contrast Induced Nephropathy

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December 8, 2011 by dailybolusoflr

Contrast Induced Nephropathy


·         Is defined as a increase in creatinine by 25% of baseline or an increase by 0.5 mg/dL within 3 days of IV contrast administration

·         Possible pathophysiologic mechanisms involve direct injury to the renal tubules; vasoconstriction leading to decreased GFR and damage by hypoxia and free radicals

·         The only uniformly agreed upon preventative therapy is intravenous hydration with normal saline

·         Other alternative methods of prevention involve administration of IV sodium bicarbonate and IV or PO

N-acetlytcsteine, but literature is not clear due to inadequate study design and conflicting study results

·         Other agreed upon risks include concurrent use of nephrotoxic drugs, continuation of metformin in the 48 hours after IV contrast and repeat contrast studies in the first 24 hours after contrast administration



Ref: http://www.ncbi.nlm.nih.gov/pubmed/16788132


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